Maintenance Therapy

Another concept, maintenance therapy, has been studied and debated among investigators over the last 5 years. Maintenance therapies focus on extending the duration of frontline treatment. There have been several reports concerning cytotoxic chemotherapy, hormonal therapy, and immunotherapy used in this manner.68-70 In 2003, a GOG trial demonstrated that maintenance paclitaxel given every 4 weeks for 12 months to patients in complete remission following standard intravenous pacli-taxel-carboplatin significantly increased the progression-free survival by 7 months compared with maintenance therapy for 3 months.71 This study's value has been controversial owing to lack of overall survival data following early closure by the data monitoring committee. Nonetheless, this was a significant improvement for these patients, some of whom began therapy with bulky, suboptimal disease; therefore, maintenance therapy should be a discussion point with patients with advanced epithelial ovarian cancer. Currently, GOG 212 is further investigating this concept in a randomized three-arm study comparing 12 months of paclitaxel versus xyotax versus observation following complete clinical response to frontline platinum/taxane treatment.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment