M

Macrophage colony-stimulating factor (M-CSF), for screening, 95 Magnetic resonance imaging (MRI)

for breast screening with BRCA mutations, 43 for detection and characterization of tumor, 66f, 67-68 for recurrent disease, 79-81, 79f, 80f for staging, 77-78 Maintenance chemotherapy, for advanced ovarian carcinoma, 159 MALDI-TOF (matrix-assisted laser desorption and ionization time-of-flight mass spectrometry), for screening, 97-98, 100t Malignant mixed mesodermal tumor, carcinogenesis of, 19t, 20

MAPK signaling pathway, in carcinogenesis, 30 Mastectomy, bilateral prophylactic, for BRCA mutation carriers, 43

Matrix-assisted laser desorption and ionization time-offlight mass spectrometry (MALDI-TOF), for screening, 97-98, 100t M-CSF (macrophage colony-stimulating factor), for screening, 95 Meigs syndrome, with fibromas, 205 MEK inhibitors, 22, 30

Melphalan, for early-stage cancer, 147, 148t, 153t

Mesothelin, for screening, 96

Metastasis(es)

distant, imaging of, 77 hepatic, resection of, 118, 118f lymph node of germ cell tumors, 213-214 imaging of, 76-77

Metastasis(es) (Continued) to ovaries, imaging of, 75-76, 75f thoracic, imaging of, 78, 78f Microinvasion, by borderline tumors, 195 Micropapillary architecture, within borderline tumors, 195 Micropapillary serous carcinoma (MPSC), carcinogenesis of, 18, 23, 25 Microsatellite instability (MSI) in carcinogenesis, 25-26, 27

in hereditary nonpolyposis colorectal cancer, 44-45, 44b Minors, genetic testing of, 48 Mitoxantrone, for early-stage cancer, 152t Mixed germ cell tumors, surgery for, 136t Mixed multivariate analysis (MMA), for screening, 95 MLH1, in hereditary nonpolyposis colorectal cancer, 45 Molecular markers, with adjuvant chemotherapy, 152154, 154t

Monoclonal antibodies, for screening, 96 Mortality, from ovarian cancer, 1, 2f, 87 MPSC (micropapillary serous carcinoma), carcinogenesis of, 18, 23, 25 MRI. See Magnetic resonance imaging (MRI). MSH2, in hereditary nonpolyposis colorectal cancer, 45 MSH6, in hereditary nonpolyposis colorectal cancer, 45 MSI (microsatellite instability) in carcinogenesis, 25-26, 27

in hereditary nonpolyposis colorectal cancer, 44-45, 44b Mucinous adenocarcinoma, metastatic, imaging of, 78, 78f Mucinous borderline tumors advanced-stage, surgery for, 134-135, 135t molecular genetic changes in, 26t Mucinous carcinoma, carcinogenesis of, 19t, 20, 26-27 Mucinous cystadenoma, imaging of, 70 Mullerian-inhibiting substance, in granulosa cell tumors, 204

Multiple markers, for screening, 95-96, 96b, 97f, 98f Multiplex arrays, for screening, 101

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