Key Points

Although there is no evidence for the curative potential of chemotherapy in recurrent or resistant ovarian cancer, improved survival associated with the delivery of several cytotoxic regimens has been documented.

Treatment in the second-line setting must attempt to carefully balance the desired effects (e.g., improvement in symptoms, delay in subsequent progression) with potential serious adverse effects.

Existing evidence supports the superiority of combination platinum-based chemotherapy, compared with single-agent platinum when used as second-line treatment of recurrent (potentially platinum-sensitive) ovarian cancer.

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