G

Gadolinium-enhanced MRI

for detection and characterization of tumor, 66f, 67-68 for recurrence, 79-80, 80f GCTs. See Granulosa cell tumors (GCTs). Gemcitabine for advanced ovarian carcinoma, 157-158, 158f for germ cell tumors, 216 for recurrent ovarian cancer, 168, 168t Genetic assessment, 47 and DNA banking, 49 genetic counseling process in, 47-48, 47f and genetic discrimination, 48 of minors, 48 referral for, 39b, 49 Genetic counseling, process of, 47-48, 47f Genetic discrimination, 48

Genetic Information Nondiscrimination Act (GINA), 48 Genetic predisposition syndrome(s), 33-49

and autosomal dominant inheritance, 34-35, 35f epidemiology of, 33, 34f, 52, 53t genetic assessment for, 47 and DNA banking, 49 genetic counseling process in, 47-48, 47f and genetic discrimination, 48 of minors, 48 referral for, 39b, 49 hereditary breast and ovarian cancer as, 35-43 BRCA genes in, 5-7, 35-36, 37f features and risks of, 7t, 36-39 genetic testing for, 39-41, 39b, 40f, 41f and lifetime risk of ovarian cancer, 52, 53t screening and risk reduction for, 42-43 hereditary nonpolyposis colorectal cancer as, 44-46 features and risks of, 44 genetic testing for, 44-46, 44b, 45b and lifetime risk of ovarian cancer, 52, 53t management of, 46 and prevention, 52 Genetic risk factors, for ovarian cancer, 5-7, 7t Genetic testing for hereditary breast and ovarian cancer, 39-41, 39b, 40f, 41f for hereditary nonpolyposis colorectal cancer, 44-46,

44b, 45b of minors, 48 Germ cell tumors, 210-217 adjuvant treatment of, 215-216 clinical characteristics of, 212-213 diagnosis of, 213 epidemiology of, 210

gross and microscopic appearance of, 211-212, 211f, 212f histologic classification of, 210, 210t outcomes with, 216-217 prognosis for, 213-214, 216-217 recurrences of, 215-217

surgical management of, 135-138, 136t, 137t, 214-215, 214f

Germ cell tumors (Continued) surveillance for, 216 tumor markers for, 212, 212t GINA (Genetic Information Nondiscrimination Act), 48 Glutathione peroxidase, in clear cell carcinoma, 27 GOG (Gynecology Oncology Group) screening study, 104-105

Gorlin's syndrome, with fibromas, 206 Grade, as prognostic factor, 10-11 Granulosa cell tumors (GCTs), 201-205 adjuvant therapy for, 202-204, 203f diagnosis of, 201 epidemiology of, 201 etiology of, 201

histology and pathology of, 201, 202f imaging of, 73

presentation of, 201

prognostic factors for, 202

recurrence of, 204

subtypes of, 201

surgical treatment for, 139f, 202, 203f surveillance for, 204 survival rates in, 202-204, 203t Granulosa-stromal cell tumors, 200-206 epidemiology of, 200 fibromas as, 203t, 205-206 granulosa cell tumors as, 201-205 adjuvant therapy for, 202-204, 203f diagnosis of, 201 epidemiology of, 201 etiology of, 201

histology and pathology of, 201, 202f presentation of, 201 prognostic factors for, 202 recurrence of, 204 subtypes of, 201

surgical treatment for, 139f, 202, 203f surveillance for, 204 survival rates in, 202-204, 203t thecomas as, 203t, 205 Gynandroblastomas, 209

Gynecology Oncology Group (GOG) screening study, 104-105

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