Several European and GOG trials over the last decade have demonstrated that carboplatin and cisplatin have equivalent efficacy in advanced epithelial ovarian cancer.52-54 In each of these trials, carboplatin not only demonstrated activity equivalent to cisplatin, but was associated with reduced gastrointestinal toxicity, renal toxicity, and neurotoxicity. Carboplatin does cause more myelosuppression than cisplatin, but in general, quality-of-life scores are better with carboplatin than with cisplatin.55
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