Environmental Factors

Additional variables have been associated with an increased risk of ovarian cancer. An example is saturated fat consumption (OR = 1.20 for each 10 g/day of intake; 95% CI = 1.03 to 1.40; P = .008).35 Clinical and epidemiologic studies have conflicting views on an association between ovarian carcinoma and talcum powder use.36,37 Coffee and tobacco consumption has not been found to be associated with an increased risk.38 Obesity is a risk factor for several hormone-related cancers, but evidence of an effect on risk of epithelial ovarian cancer remains inconclusive. Some studies have shown a positive correlation between early adulthood obesity and ovarian cancer.39 Alcohol consumption has not been associated with increased risk.40,41 A history of pelvic inflammatory disease and endometriosis (endometrioid and clear cell histologies) has been associated with ovarian cancer.42,43

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