Ovarian cancer is one of the most chemotherapy-sensitive malignancies, with 60% to 80% of women with newly diagnosed advanced disease anticipated to achieve both substantial objective and subjective responses to primary therapy.1 Despite this fact, most women who respond to this treatment ultimately experience a relapse of the disease process.2 Thus, the need to ultimately consider a second-line treatment strategy in ovarian cancer is the rule, rather than the exception. This chapter reviews the status of chemotherapeutic management options in the ovarian cancer patient who fails to respond to primary treatment or whose disease progresses after a response to initial therapy.
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