Encapsulation

The simplest way to provide a dose unit comprising microparticles is to fill into capsules. No special technology is required and coat rupture is not an issue as mechanical stress or high-pressure compaction is not employed. Neither are additional excipients necessary (except possibly a low level of lubricant). Volumetric or dosator filling devices are both suitable for encapsulation. A separate chapter in this book discusses capsules for use with controlled release preparations (Fig. 13.11).

Fig. 13.11 Different capsule filling principles for multiparticulates. (a) Double slide filling, (b) dosage cylinder filling, (c) dosage tube filling, and (d) slide/piston dosing method

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