• Grape seed extracts are rich in polyphenolic compounds.
• Various polyphenolic compounds have shown an antibacterial effect.
• Grape seed extracts exhibit strong antibacterial activity against many bacteria.
• Acetone: water: acetic acid and methanol: water: acetic acid extracts of grape seeds showed higher antibacterial activity against gram-positive bacteria than gram-negative bacteria.
• Numerous studies have reported grape seed extracts not to be toxic.
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