Summary Points

• The ethno-medicinal literature reveals that Swietenia macrophylla seeds have long been used in Indonesia as a folk medicine treatment for diabetes.

• Preliminary pharmacological assay revealed that Swietenia macrophylla seeds possess significant hypoglycemic activity in experimental diabetic rats.

• Swietenia macrophylla seeds produce their hypoglycemic effect by improving peripheral glucose utilization.

• Swietenine, a novel hypoglycemic molecule, was identified employing bioassay guided isolation.

• In vivo antidiabetic bioassay of swietenine revealed that it exhibited significant hypoglycemic and hypolipidemic activity at the doses of 25 and 50 mg/kg p.o.

• Acute and subacute toxicity studies revealed that swietenine is non-toxic at its therapeutic dose in experimental animals.

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Health And Fitness 101

Health And Fitness 101

Self-improvement is a thing which you must practice throughout your life because once you started to believe that you are perfect then, things will start to become complex. You need to know that no one is perfect and no one can be perfect.

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