• The ethno-medicinal literature reveals that Swietenia macrophylla seeds have long been used in Indonesia as a folk medicine treatment for diabetes.
• Preliminary pharmacological assay revealed that Swietenia macrophylla seeds possess significant hypoglycemic activity in experimental diabetic rats.
• Swietenia macrophylla seeds produce their hypoglycemic effect by improving peripheral glucose utilization.
• Swietenine, a novel hypoglycemic molecule, was identified employing bioassay guided isolation.
• In vivo antidiabetic bioassay of swietenine revealed that it exhibited significant hypoglycemic and hypolipidemic activity at the doses of 25 and 50 mg/kg p.o.
• Acute and subacute toxicity studies revealed that swietenine is non-toxic at its therapeutic dose in experimental animals.
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