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Crabs Eye (Abrus precatorius) Seed and Its Immunomodulatory and Antitumor Properties

Sujit K. Bhutia1, Tapas K. Maiti2

1 Department of Life Science, National Institute of Technology, Rourkela, Orissa, India

2 Department of Biotechnology, Indian Institute of Technology, Kharagpur, India

CHAPTER OUTLINE

Introduction 410 Botanical Description 410 Historical Cultivation and Usage 411

Present-Day Cultivation and Usage 411

Applications to Health Promotion and Disease Prevention 411

Antitumor properties 411 Immunostimulatory properties 413 Adverse Effects and Reactions (Allergies and Toxicity) 414 Summary Points 414 References 415

LIST OF ABBREVIATIONS

ABP, abrin-derived peptide ABR, abrin

ADCC, antibody dependent cellular cytotoxicity AGG, agglutinin

AGP, agglutinin derived peptide

DL, Dalton's lymphoma

EAC, Ehrlich's ascites carcinoma

ER, endoplasmic reticulum

IL-2, interleukin-2

IFN-g, interferon-g

NK, natural killer

RIP-II, ribosome inactivating proteins-II TAM, tumor associated macrophage TDA, tryptic digest of Abrus agglutinin TNF-a, tumor necrosis factor-a

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