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Bambangan (Mangifera pajang) Seed Kernel: Antioxidant Properties and Anti-cancer Effects

Mohd Fadzelly Abu Bakar1, Maryati Mohamed1, Asmah Rahmat2, Jeffrey R. Fry3

1 Laboratory of Natural Products, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia

2 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia

3School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, United Kingdom

CHAPTER OUTLINE

Introduction 184 Botanical Description 184 Historical Cultivation and Usage 185

Present-Day Cultivation and Usage 185

Applications to Health Promotion and Disease Prevention 185

Phytochemical components 185 Antioxidant activity 186 Anticancer activity 186 Cytoprotective activity 186 Adverse Effects and Reactions (Allergies and Toxicity) 187 Summary Points 187 References 187

LIST OF ABBREVIATIONS

Caov3, human ovarian carcinoma cell line DPPH, 1,1-diphenyl-2-picrylhydrazyl FRAP, ferric reducing/antioxidant power GR, glutathione reductase GSH, glutathione

HepG2, human Caucasian hepatoma carcinoma cell line HPLC, high performance liquid chromatography HT-29, human colon carcinoma cell line MCF7, Hormone-dependent breast carcinoma cell line

MDA-MB-231, non-hormone-dependent breast carcinoma cell line MTT, 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide t-BHP, tertiary-butyl hydroperoxide

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