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Therapeutic Effects of Grains of Paradise (Aframomum melegueta) Seeds

Solomon Umukoro, Aderemi Caleb Aladeokin

Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria

CHAPTER OUTLINE

Introduction 535 Botanical Description 536 Historical Cultivation and Usage 537

Present-Day Cultivation and Usage 538

Applications to Health Promotion and Disease Prevention 538 Adverse Effects and Reactions (Allergies and Toxicity) 541 Summary Points 542 References 542

LIST OF ABBREVIATIONS

AM, Aframomum melegueta

ASA, acetylsalicylic acid

CNS, central nervous system

COX-2, cyclo-oxgenase-2

FDA, Food and Drug Administration

GP, grain of paradise

MDA, malonyldialdehyde

NSAIDs, non-steriodal anti-inflammatory drugs

PHZ, phenylhydrazine

PW, paw withdrawal

RA, rheumatoid arthritis

WBC, white blood cell

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