Piceatannol an Antitumor Compound from Euphorbia lagascae Seeds

Maria-Jose U. Ferreira1, Noelia Duarte1, Krystyna Michalak2, Andras Varga3, Joseph Molnar4

1iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal 2Wroc1aw Medical University, Department of Biophysics, Wroclaw, Poland

3 Department of Molecular Parasitology, Humboldt University, Berlin, Germany

4 Department of Medical Microbiology, University of Szeged, Szeged, Hungary

CHAPTER OUTLINE

Introduction 453 Botanical Description 454 Historical Cultivation and Usage 454

Present-Day Cultivation and Usage 454

Applications to Health Promotion and Disease Prevention 454 Adverse Effects and Reactions (Allergies and Toxicity) 459 Summary Points 459 References 459

LIST OF ABBREVATIONS

BCECF, 2',7'-bis-(3-carboxypropyl)-5-(and-6)-carboxyfluorescein

FAR, fluorescence activity ratio value

MDR, multidrug resistance

MRP, Multidrug resistance associated protein

P-gp, P-glycoprotein

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