N A

INHIBITION OF CELL PROLIFERATION INDUCTION OF CELL DIFFERENTIATION INDUCTION OF APOPTOSIS

INVASION ADHESION MOLECULES ANGIOGENIC FACTORS

ANTI-ANGIOGENESIS

FIGURE 11.1

Initiation, promotion, and progression steps of carcinogenesis process. The repairing mechanisms of chemopreventive phytochemicals.

Phytochemicals act on the initiation, promotion, and progression phases of carcinogenesis through different mechanisms of action.

that exhibit continuous disturbance of cellular and molecular signal cascades (Vincent & Gatenby, 2008) (Figure 11.1).

It has been estimated that 30—40% of all cancers can be prevented by appropriate diet, physical activity, and maintenance of appropriate weight (Rigas et al., 2008). Epidemiological evidence, cell culture, and animal tumor model studies have demonstrated that a large number of natural compounds present in the diet could lower cancer risk and even sensitize tumor cells in anticancer therapies (de Kok et al., 2008). Figure 11.2 shows the main molecular targets of bioactive phytochemicals.

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Health And Fitness 101

Health And Fitness 101

Self-improvement is a thing which you must practice throughout your life because once you started to believe that you are perfect then, things will start to become complex. You need to know that no one is perfect and no one can be perfect.

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