INHIBITION OF CELL PROLIFERATION INDUCTION OF CELL DIFFERENTIATION INDUCTION OF APOPTOSIS
INVASION ADHESION MOLECULES ANGIOGENIC FACTORS
Initiation, promotion, and progression steps of carcinogenesis process. The repairing mechanisms of chemopreventive phytochemicals.
Phytochemicals act on the initiation, promotion, and progression phases of carcinogenesis through different mechanisms of action.
that exhibit continuous disturbance of cellular and molecular signal cascades (Vincent & Gatenby, 2008) (Figure 11.1).
It has been estimated that 30—40% of all cancers can be prevented by appropriate diet, physical activity, and maintenance of appropriate weight (Rigas et al., 2008). Epidemiological evidence, cell culture, and animal tumor model studies have demonstrated that a large number of natural compounds present in the diet could lower cancer risk and even sensitize tumor cells in anticancer therapies (de Kok et al., 2008). Figure 11.2 shows the main molecular targets of bioactive phytochemicals.
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