Safflower (Carthamus tinctorius L.) is cultivated for the edible oil that can be obtained from its seeds. The oil of the safflower seed (OSS) contains polyunsaturated fatty acids, including a mixture of linoleic (LA) (more than 70%), oleic, and other acids, as well as serotonin and its conjugates, polyphenols, lignans, and other compounds.
The main new development for therapeutic use of OSS is its characteristic analgesic activity. OSS, prepared by pressing Carthamus tinctorius seeds, has moderate analgesic activity, and has been used for many years in Korean herbal acupuncture (Popov et al., 2009). In this chapter, new data are presented from studies done on serotonin content in OSS, the analgesic properties of OSS in a model of functional blockade of the sciatic nerve in mice, and other pharmacological activities. The putative mechanisms of the actions of OSS components are discussed.
Was this article helpful?