Antidiabetic Activities of Fenugreek Trigonella foenumgraecum Seeds

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Sirajudheen Anwar1, Sandhya Desai1, Maryam Eidi2, Akram Eidi3

1 Department of Pharmacology, Prin. K.M. Kundanai College of Pharmacy, Cuffe Parade, Mumbai, India

2 Department of Biology, Varamin Branch, Islamic Azad University, Varamin, Iran

3 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

CHAPTER OUTLINE

Introduction 469 Botanical Description 470 Historical Cultivation and Usage 470

Present-Day Cultivation and Usage 470

Applications to Health Promotion and Disease Prevention 470

Fenugreek galactomannan in diabetes mellitus 470

Different modes of pharmacological action 471

Glucose uptake by peripheral cells and tissues 473

Effect of fenugreek galactomannan on biochemicals 473 Effect of fenugreek galactomannan on histopathological findings of the pancreas 474 Effect of alcoholic extracts of fenugreek seeds on diabetes mellitus 474 Adverse Effects and Reactions (Allergies and Toxicity) 476 Summary Points 477 References 478

LIST OF ABBREVIATIONS

ALP, alkaline phosphatase ALT, alanine aminotransferase AST, aspartate aminotransferase GL, galactomannan MDA, malonyl dialdehyde

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