More than half of molybdenum in liver occurs as non-pro tern-bound di-lcarboxy-aminomethyl) molybdopterin in the outer mitochondrial membrane; most of the remainder is in the form of enzvme-bound molybdopterin (Nielsen. 1994). Total molybdenum concentration in human liver is about 0.9 p.g g.


Less than 1% of systemic Mo is excreted with bile (Nielsen. 1994). Between 60 and 90% of ingested molybdenum is excreted with urine (Tumlund et al., 1995), A significant

Figure >1.20 Molybdenum cofartor synthesis

proportion of filtered molybdenum is recovered, but the mechanism of renal reab-sorpiion remains unclear (Tumlund ci at., 1995). Ultimately, molybdopterin is catabolized to the sul(ur-containing pterin urnthione and molybdenum is released.

Urothione is mostly excreted with urine (Johnson and Rajagopalan, I9S21; the amounts in urine reflect molybdopterin synthesis.


It has been suggested that molybdenum homeostasis is regulated via the rate of molybdate excretion with urine (Turnlund ei at,, 1995), but the involved mechanisms remain unclear.



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