Folate

Folate (folic acid, N-[4-[ f (2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]ben-zoyI]-L-glutamic acid, pteroy (glutamic acid. PC A. obsolete names vitamin B8, vitamin B9. vitamin Be. vitamin M; molecular weight 441 ) is one of several biological active vitamers; compounds with comparable activity include the physiological metabolites 7.8-dihydrofolate, 5,6,7,8-tetrahydrofolate (THF), 5,10-methylenc-THF, methyl-THF, 5-formimino-THF, 10-formyi-THF, 5-formyl-THF (folinic acid citrovorum factor, leucovorin >,

Abbreviations p-acetamidobenzoylglutamate di hydro fol a te formtminoglutamate folate receptor multidrug resistance protein 2 (ABCC2J methylenetetrahydrofolate dehydrogenase (EC! ,5.1.5) para-aminobenzoic acid reduced folate carrier gene (SLC19A1) 5,6,7,8-tetrahydrofolate apBCIu DHF FIGLU FR

MRP2

MTHFD

pABC

RFC1

N NH

HjC H NH

C=0 HN CH-COOH

ÇH; Folate 7.8-Dihydrofolate

COOH

HaC H H NH

5-Formimino-THF

5-Formyt-THF

10-Formyl-THF

HjC H H NH

HjC H H

HjC H H NH

y

c=o

HN

CH-COOH

ÇHï

ÇH3

ç>o

I

NH

CH-COOH

CH,

ÇH;

Ç-0

NH

CH-COOH

CHj

ÇHî

COOH

Polygtulamyl-5.6.7,8-tetra hydro • folate (THF)

Polygtulamyl-5.6.7,8-tetra hydro • folate (THF)

Methyl-THF

5,1D-Methylene-TH F 5,10-Methenyl-THF

Flgu» 10.28 Important folate vitamers

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