Oral zinc sulfate (10 mg/kg) supplements administered in three divided doses per day (up to 600 mg/day) for 2 months completely cleared recalcitrant viral warts in 87% of patients, according to a single-blind, placebo-controlled trial of 80 volunteers with at least 1 5 viral warts that were resistant to other treatments (Al Gurairi et al 2002). Warts were completed cleared in 61 % of patients after 1 month of treatment, whereas none of the patients receiving placebo reported a successful response and some developed new warts. In both placebo and treatment groups the drop-out rates were high: 50% and 45% respectively. Interestingly, patients in the treatment group with low serum zinc baseline levels (mean 62.4/jg/100 mL) exhibited no signs or symptoms of deficiency and zinc serum levels failed to rise in the patients who remained resistant to zinc therapy. Treatment with high-dose zinc supplements was © 2007 Elsevier Australia

accompanied by nausea and in some cases vomiting and mild epigastric pain, although these symptoms were described as mild and transient.

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