Although a number of uncontrolled studies testing combination treatments have been promising, folate has never been assessed as a sole treatment. As such, it is difficult to determine its role in the treatment of this condition. In previous studies, a combination of oral folic acid and vitamin B12, together with increased sun exposure, has produced response rates in the vicinity of 50% (Juhlin & Olsson 1997). A more recent controlled study by a different group of researchers found that exposure to a specific band width of UV radiation produced repigmentation in 92% of subjects, irrespective of vitamin supplementation (Tjioe et al 2002).

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