Beta-carotene is readily converted into vitamin A when required by the body and is considered to be non-toxic, even when given in doses as high as 300 mg/day (Mathews-Roth 1990a, 1993).

A review of the literature on adverse effects of carotenoids on human and animal development suggests that beta-carotene does not have any genotoxic affects (Mathews-Roth 1988) and a toxicity study performed on rats suggests a no-observed-adverse-effect-level (NOAEL) is at a dietary level of at least 5.0% or more than 3000 mg/kg/day (Nabae et al 2005). Beta-carotene overdose is not reported in the literature.

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