Vitamin E is relatively non-toxic. It is not stored as readily in the body as other fat-soluble vitamins and up to 60-70% of a daily dose is excreted in the faeces. Doses as high as 3200 mg/day have been used for 12 years with few adverse effects (Fariss & Zhang 2003).

In April 2000, the Food and Nutrition Board of the Institute of Medicine in the United States set an upper tolerable limit of 1 500 IU of RRR-alpha-tocopherol as the highest dose unlikely to result in haemorrhage in most adults.

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