No toxic effects have been found in rats (Mancebo et al 2002) even when given doses up to 80 miykg (Wang et al 2002). No allergic responses were reported from allergenicity studies using guinea pigs (Wang et al 2002).

Three case of hepatotoxicity related to noni juice consumption have been reported, with one case requiring urgent liver transplantation (Millonig et al 2005, Stadlbauer et al 2005) and the others recovering spontaneously after ceasing noni consumption (Millonig et al 2005, Stadlbauer et al 2005).

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