Symptoms of toxicity include paraesthesia, hyperaesthesia, bone pain, muscle weakness, numbness and fasciculation, most marked at the extremities (Dalton & Dalton 1 987, Diegoli et al 1 998). Vitamin B6 1252

The dose and time frame at which toxicity occurs varies significantly between individuals. Studies involving large population groups using 100-1 50 mg/day have shown minimal or no toxicity in 5- to 10-year studies, whereas women self-medicating for PMS taking 117 ± 92 mg for 2.9 ± 1.9 years have reported increased incidence in peripheral neuropathy in others (Bernstein 1990, Dalton & Dalton 1987).

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