As vitamin B5 is essential for adrenal cortex function and the synthesis of steroid hormones, it is often used together with other B vitamins during times of 'stress' in order to improve the body's response and restore nutrient levels. Interestingly there were a large number of experiments conducted in the 1950s, attempting to elicit the impact of pantothenic acid deficiency on adrenal function and stress response in animals; however, little research has been done since. A small study demonstrated that injections of pantothenic acid in B5-deficient rats were corrective of the deficiency picture and had a steroidogenous effect.

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