Intraperitoneal and intravenous injections of peppermint oil and its constituents, 1,8-cineol, menthone, isomenthone, menthol, pulegone, menthyl acetate and caryophyllene, dramatically increased ambulatory activity in mice. It is thought that the effect is mediated via a dopaminergic effect of menthol. This may explain the traditional use of peppermint for mental fatigue (Umezu & Morita 2003, Umezu et al 2001). Inhalation of peppermint oil has also been shown to have a stimulant effect on mice in a forced swimming test, with the effect remaining when over-agitation was induced by intraperitoneal caffeine (Lim et al 2005).

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