Significant Interactions

Controlled studies are not available; therefore, interactions are based on evidence of activity and are largely theoretical and speculative. TRICYCLIC ANTIDEPRESSANTS AND OTHER SEROTONERGIC AGENTS

Theoretically, co-administration may result in an increased risk of serotonin syndrome. However, one experimental study found that brain SAMe levels were significantly reduced after chronic treatment with imipramine (Taylor & Randall 1975) — use this combination with caution.

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