Significant Interactions

Controlled trials exist that have identified drug interactions. However, in most cases, the interactions are based on evidence of pharmacological activity, case reports or theoretical reasoning. The DGL form is considered safer and less likely to result in drug interactions. ANTICOAGULANTS

Isoliquiritigenin inhibits platelet aggregation and GL inhibits prothrombin according to in vitro and in vivo tests (Francischetti et al 1997, Kimura et al 1993a, Tawata et al 1992). Whether the effect is clinically significant for licorice remains to be determined — use high doses with caution.

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