Significant Interactions

Controlled studies are not available; therefore, interactions are based on evidence of activity and are largely theoretical and speculative. Preliminary evidence of CYP3A4 inhibition suggests it could theoretically increase levels of drugs metabolised, although a 2003 crossover study found no evidence of significant effect (DiCenzo et al 2003). WARFARIN

Elevation of serum warfarin levels is theoretically possible owing to CYP inhibition seen in vitro — use this combination with caution.

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