Significant Interactions

Antibiotic administration blocks metabolism of isoflavones to equol through inhibition of the intestinal microflora, whereas a high carbohydrate milieu increases intestinal fermentation and results in more extensive bio-transformation of physto-oestrogens (Setchell & Cassidy 1999).

It has been suggested that isoflavones can inhibit the oxidative and conjugative metabolism of drugs in vitro and interact with transporters such as P-glycoprotein; however, their ability to interact with drugs remains uncertain (Evans 2000). CALCIUM, MAGNESIUM, ZINC, COPPER AND IRON

Soy contains phytic acid, which may bind with certain minerals, such as calcium, magnesium, manganese, zinc, copper and iron, reducing their availability (PDRHealth 2004).

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