Significant Interactions

Controlled studies are not available for many Interactions; therefore they are based on evidence of activity and are largely theoretical and speculative. WARFARIN

Due to the herb's antiplatelet effects there is a theoretical risk of increased bleeding at high doses (> 10 g) although this is not evident clinically. There is no evidence of an interaction with warfarin at the usual dietary and therapeutic intakes (Jiang et al 2005, Stenton et al 2001, Vaes & Chyka 2000), and ginger has been shown not to alter prothrombin times in pooled human plasma collected from male volunteers between the ages of 18 and 57 years (Jones et al 2001). A standardised ginger extract, EV.EXT 33, has demonstrated no significant effect on coagulation parameters or on warfarin-induced changes in blood coagulation in rats (Weidner & Sigwart 2000) and ginger was found not to affect clotting status or the pharmacokinetics or pharmacodynamics of warfarin in healthy human subjects (Jiang et al 2005). Avoid high-dose supplements unless under medical supervision.

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