Sickle Cell Disease

Orally administered L-GIn improves the nicotinamide adenosine dinucleotide (NAD) redox potential of sickle red blood cells (RBC). Investigations of blood samples taken from five adult patients with sickle cell anaemia who had been on L-GIn (30 g/day) therapy for at least 4 weeks consistently resulted in improvement of sickle RBC adhesion to human umbilical vein endothelial cells compared to the control group. The authors conclude that these results suggest positive physiological effects for L-GIn in sickle cell disease (Niihara et al 2005).

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