Periodontal Disease

A series of RCTs has shown that rinsing with a solution of folate (5 mg/dose) twice daily alleviates gingival inflammation in all age groups and in pregnant and nonpregnant women (Pack 1984, Thomson & Pack 1982). Treatment results in a significant reduction in inflammation without altering plaque levels or folate serum status and appears to be more successful than oral supplements (Vogel et al 1976).

Preliminary evidence suggests that topical folate may also have a role in controlling gingival hyperplasia associated with long-term phenytoin use (Drew et al 1987).

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