Peptic Ulcer And Dyspepsia

The anti-inflammatory, mucoprotective and anti-ulcer activities of licorice make it an attractive treatment for peptic ulcer. While these effects have been attributed to the GL and GA constituents, the DGL, which contains <3% GL, has also been investigated and appears to produce the most promising results when used long term (Bardhan et al 1978, Larkworthy & Holgate 1975). DGL also promotes differentiation of undifferentiated cells to mucous cells and stimulates mucus production and secretion (van Marie etal 1981).

In an uncontrolled trial of 32 patients with chronic duodenal ulcer, 3800 mg/day of DGL (in five divided doses) produced signs of healing in all cases and total restoration of mucosa in a majority of subjects. Although treatment continued for 24 weeks, considerable improvement was seen in 56% of patients by week 12 and in

78% by week 16 (Larkworthy & Holgate 1975). A shorter 4-week trial of 96 patients with gastric ulcer failed to produce the same positive results (Bardhan et al 1978).

DGL plus antacid (Caved-S; 2 tablets chewed three times daily between meals) was as effective as cimetidine (200 mg three times daily plus 400 mg at night) after 6 weeks, according to one randomised single-blind trial of 100 volunteers with peptic ulcer. The two treatments continued to produce similar results after 12 weeks and recurrence rates after both medications were reduced were also similar (Morgan et al 1982).

Commission E approves the use of licorice for the treatment of gastric and duodenal ulcers (Blumenthal et al 2000).

Herbal Remedies For Acid Reflux

Herbal Remedies For Acid Reflux

Gastroesophageal reflux disease is the medical term for what we know as acid reflux. Acid reflux occurs when the stomach releases its liquid back into the esophagus, causing inflammation and damage to the esophageal lining. The regurgitated acid most often consists of a few compoundsbr acid, bile, and pepsin.

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