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A Chinese report of successful treatment of angina pectoris with the saponin content of tribulus suggests that the preparation dilates coronary arteries and improves coronary circulation (Wang et al 1990).

In another study 10 mg/kg/day of the aqueous extract of the fruit has shown antihypertensive effects in an animal trial when compared to control. The authors concluded that effects are possibly due to inhibition of ACE activity (Sharifi et al 2003). Tribulus 1147

Experiments with healthy mice have found Tribulus terrestris significantly inhibits gluconeogenesis and influences glycometabolism and reduces triglyceride and total cholesterol levels (Li etal 2001).

A dose-dependent antispasmodic activity causing a significant decrease in peristaltic movements has been demonstrated with the isolated saponin content of tribulus (Arcasoy etal 1998).

More recently, an in vitro test has also identified COX-2 inhibition activity (Hong et al 2002), suggesting possible anti-inflammatory actions.

Two isolated constituents tribulosin and beta-sitosterol-d-glucoside have shown anthelmintic activity in vitro against Caenorhabditis elegans (Deepak et al 2002).

Of eight steroid saponins tested, two showed potent antifungal activity against Candida albicans, with one, TTS-12, demonstrating its ability to decrease virulence and destroy the cell membrane (Zhang et al 2005).

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