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In vitro and in vivo evidence suggests that harpagoside may exhibit cardiac affects and lower blood pressure, heart rate and reduce arrhythmias (Fetrow & Avila 1999). As an extremely bitter herb, devil's claw is thought to increase appetite and bile production.. Diterpenes extracted from the roots and seeds of devil's claw exhibited selective antiplasmodial activity in vitro (Clarkson et al 2003), which may have future relevance in view of the increasing resistance to conventional antimalarials.

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