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An increased risk of side-effects such as hypokalemia, fluid retention and elevated blood pressure due to increased mineralocorticoid effect exists. This has been demonstrated in case reports (Bernardi et al 1994, deKlerk et al 1997) — use this combination with caution when licorice is used in high dose or for more than 2 weeks and observe patients closely.

DIURETICS (INCLUDING LOOP: THIAZIDE AND POTASSIUM-SPARING)

Case reports exist in which patients experience hypokalemia and hypertension with concomitant use of licorice and diuretics (deKlerk et al 1997, Farese et al 1991, Folkerson et al 1996) due to increased potassium excretion. Avoid long-term use of licorice and diuretics concurrently unless under professional supervision. Monitor potassium levels.

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