Nfkappab Inhibition

The many and varied effects of curcumin may be partly associated with the inhibition of transcription factor nuclear factor-kappa beta (NF-kappa-B) and induction of heat shock proteins. NF-kappa-B is a transcription factor pivotal in the regulation of inflammatory genes and is also closely associated with the heat shock response, which is a cellular defence mechanism that confers broad protection against various cytotoxic stimuli. Inhibition of NF-kappa-B may reduce inflammation and protect cells against damage (Chang 2001) and curcumin has been found to attenuate experimen

tal colitis in animal models through a mechanism correlated with the inhibition of NF-kappa-B (Salh et al 2003). The clinical significance of this is unclear.

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