Silymarin demonstrated neuroprotective activity according to preliminary research. A study by Wang et al (2002) demonstrated that silymarin could effectively protect dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting activation of the microglia that represent resident macrophage-like population of St Mary's thistle 1042

brain cells acting in host defence and tissue repair in the CNS. Silymarin induced an

increase of reduced glutathione and ascorbic acid levels and superoxide dismutase activity in the brain of treated rats (200 mg/kg/day PO) for 3 days, showing a protective effect on antioxidant defence systems.

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