Creatine supplementation has displayed neuroprotective effects in several animal models of neurological disease, such as Huntington's disease, Parkinson's disease, or motor neurone disease (MND) (also known as amyotrophic lateral sclerosis) (Andreassen et al 2001, Dedeoglu et al 2003, Ferrante et al 2000, Wyss & Schulze 2002) and is currently being evaluated in early stage trials in Parkinson's disease and MND (Beal 2003). A number of theories of a possible mechanism for neuroprotection have been put forward. One theory proposes that creatine exerts antioxidant activity and mitochondrial stabilising effects, two mechanisms of benefit in neurodegenerative diseases, which are characterised by mitochondrial dysfunction and Creatine 331 oxidative damage (Shefner et al 2004).

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