Nephroprotective Effect

In vitro experiments with kidney cells damaged by paracetamol, cisplatin or vincristin demonstrate that administration of silybin before or after the chemical-induced injury can lessen or avoid the nephrotoxic effects (Sonnenbichler et al 1999). Animal studies have confirmed the nephroprotective effect for cisplatin-induced injury (Karimi et al 2005). In one study, the effects of cisplatin on glomerular and proximal tubular function as well as proximal tubular morphology were totally or partly ameliorated by silybin (Gaedeke et a I 1996).

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