Modulates Cytochrome P450

Garlic may have the potential to alter CYP450 enzymes; however, results from in vitro, animal and human studies are confusing. Garlic oil induced CYP450 according to one animal study (DaIvi 1992), whereas in vitro tests failed to identify an inhibitory effect on cytochrome P450 (2C9*1, 2C19, 3A4, 3A5 and 3A7) (Foster etal 2001). Other researchers using human volunteers found that garlic oil reduced CYP2E1 activity by 39%, but had no effect on CYP1A2, CYP2D6 or CYP3A4 activity (Gurley et al 2002).

Recently, an interaction between saquinivir and garlic has been reported, suggestive of a CYP induction effect, but human tests do not support this theory (Piscitelli etal 2002).

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