Mitochondrial Myopathy

An open multicentre study involving 44 volunteers with mitochondrial myopathies showed that treatment with CoQ10 (2 mg/kg/daily) over 6 months decreased postexercise lactate levels by at least 25% in 16 patients. Of those responding, a further 3 months' treatment with either CoQ10 or placebo produced no significant differences (Bresolin et al 1990).

HUNTINGTON'S CHOREA

A randomised double-blind study involving 347 patients with early Huntington's chorea showed that a dose of CoQ10 (600 mg/day) taken over 30 months produced a trend towards slow decline as well as beneficial trends in some secondary measures; however, changes were not significant at this dosage level (Huntington's Study Group 2001).

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