Methotrexate Toxicity

Methotrexate is a cytotoxic drug with folate antagonist properties. In part, its efficacy is dependent on this effect, but severe deficiency symptoms such as macrocytic anaemia are sometimes induced (Lambie et al 1985). Co-administration of folic acid or folinic acid has been investigated as preventative treatment, with both forms Folate 477

capable of reducing drug side-effects (Ortiz et al 1998, Strober & Menon 2005).

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