Male Fertility

A placebo-controlled, double-blind crossover trial of 100 infertile males (aged 20-40 years) found that l-carnitine therapy (2 g/day) was effective in increasing semen quality, sperm concentration and total and forward sperm motility, especially in groups with lower baseline levels (Lenzi et al 2003). The positive effects on sperm motility have also been shown in previous trials using l-carnitine 3 g/day (Costa et al 1994, Vita I i et al 1995). In a later trial, improvements in sperm motility were only observed in the presence of normal mitochondrial function, determined by phospholipid hydroperoxide glutathione peroxidase levels (Garolla et al 2005).

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