In vitro and in vivo studies have identified considerable antimalarial effects (Najib et al 1999, Siti Najila et al 2002). Administration of andrographis immediately after infection and for an additional 4 days extended the life span of mice infected with Plasmodium berghei strain ANKA (Rahman et al 1999). Four xanthones recently isolated from A. paniculata have demonstrated antimalarial activity against Plasmodium berghei in vivo (Dua et al 2004). Treatment with 30 mg/kg for 4 days produced a 62% decrease in parasites in infected mice.

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