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Adhatoda has not been significantly investigated in clinical studies, so information is generally derived from in vitro and animal studies and is largely speculative. As with many Ayurvedic herbs, most investigation has been undertaken in India and locating original research from these sources is difficult. ANTITUSSIVE EFFECTS

Results from animal studies show that Adhatoda vasica extract exerts considerable antitussive activity when administered orally and is comparable to codeine when cough is due to irritant stimuli (Dhuley 1999). The antitussive activity may be due to the action of vasicinone and vasicinol, which have activity in the cerebral medulla.

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