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Pygeum has demonstrated several different pharmacological effects according to In vitro and in vivo data; however, these are not well defined. HORMONAL EFFECTS

In vivo studies have shown that orally administered pygeum extract has a significant effect on dihydrotestosterone (DHT)-induced prostatic enlargement (Choo et al 2000, Yoshimura et al 2003). Pretreatment with pygeum extract counteracted the effect of DHT-induced prostate enlargement (Choo et al 2000), and the more recent study found that oral administration of pygeum extract suppressed the effects of DHT on micturition (Yoshimura et al 2003) and effectively suppressed prostatic growth when co-administered with DHT; however, it did not reverse established prostatic growth when administered after DHT.

Phytoestrogens found in pygeum can exert either an oestrogenic or anti-oestrogenic effect depending on the dose, according to other in vivo tests (Mathe et al 1995) and may also contribute to its effects in the prostate.

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