Pantethine, a metabolite of pantothenic acid, has been investigated in several clinical studies and found to exert significant lipid-lowering activity (Coronel et al 1991, Donati et al 1986, Gaddi et al 1984).

The mechanism of action relates to reduced insulin resistance and activation of Iipolysis in serum and adipose tissue, according to in vivo research (Naruta & Buko 2001). Additionally, inhibition of HMG-CoA reductase, as well as more distal enzymes in the cholesterol synthetic pathway, are likely to be responsible (McCarty 2001). More recently, an in vitro study demonstrated that pantethine produced a 50% inhibition of fatty acid synthesis and an 80% inhibition of cholesterol synthesis (McRae 2005).

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